U.S. Secretary of State Marco Rubio said on Wednesday the United States is still willing to negotiate an end to the Iran crisis but Tehran is not serious about talks, as the widening conflict disrupted two of the world's most critical energy chokepoints. Rubio made his comments in a meeting of Southeast Asian foreign ministers a day after three oil tankers carrying crude to Asia reversed course in the Red Sea, apparently in response to threats from Yemen's Iran-aligned Houthis. With Iran already threatening shipping through the Strait of Hormuz leading out of the Gulf, the Red Sea has served as the main alternate route.A senior Iranian official told Reuters on Monday that Tehran had received a proposal from mediators for a 10-day ceasefire in efforts to salvage the interim ceasefire agreement signed by the U.S. and Iran in June, which replaced an earlier April ceasefire.In another sign that diplomacy remains alive, Iran's Interior Minister Eskandar Momeni has visited mediator Pakistan and asked Islamabad to continue its efforts.Rubio said Washington was "always committed to diplomacy" but doubted whether Tehran was equally committed to negotiations."The problem we're having right now is that they're not serious about talks. If they're serious, we're serious. If they're not, then we will do what's necessary to protect our interests, and also the interests of our allies," Rubio said in Manila.He stressed that Iran could not be allowed to control the Strait of Hormuz, arguing it would create a dangerous precedent for the world including Southeast Asian countries.With no diplomatic breakthrough in sight, the U.S. military bombed targets across Iran for an 11th straight night on Tuesday. Tehran residents reported hearing explosions in the early hours of Wednesday as Iran activated its air defences over the capital, Iran's semi-official Fars news agency said.Explosions were also reported in the southeastern coastal cities of Chabahar and Konarak, and two blasts were heard in Bushehr, home to Iran's only nuclear power plant, Iran's official IRNA news agency reported.Earlier, Iran targeted U.S. military sites in Bahrain, Kuwait and Jordan and a tanker was hit in the Strait of Hormuz.Iran said it had struck infrastructure belonging to Amazon in Bahrain, where the U.S. tech company operates a regional data centre. Amazon did not comment and Reuters could not verify the report.U.S. President Donald Trump confirmed that 18 U.S. service members had been killed so far in the war, including four in Iranian attacks on U.S. military bases in Jordan and Iraq over the last few days. Oil prices rose further in Asian trade on Wednesday after climbing more than 2% on Tuesday following the Houthi threats, with Brent crude hovering above $91 a barrel and U.S. gasoline back over $4 a gallon.